Explanation of HSCT procedure:

Stem cells are mostly obtained from the peripheral blood.

In order to get that, a patient must receive a conditioning regimen which involves chemotherapy that targets components of the immune system, and mobilization of the stem cells from the bone marrow into the peripheral blood.

A non-myeloblative conditioning regimen of chemotherapy induces an immediate immune seize fire. A new immune system is regenerated that defaults to self tolerance. Equilibrium is restored in the new immune system by “rebooting” it.

The equilibrium is the goal of the stem cell transplant; allowing the disease to go into remission, stopping the progression and also, reversing the disease symptoms.

Entire detailed HSCT procedure that I am going through.

Terms

Chemotherapy – used to kill the T cells that cause inflammation, and mobilize stem cells out of the bone marrow.

Filgrastim – A drug given to make the body mobilize stem cells out of the bone marrow.

Cell Harvesting – The extracting of stem cells from your body.

Cell Placement – The actual transplant of the stem cells that were extracted from your body.

Neutropenic – A state of the body where your immune system is extremely low. Caution is required on these days.

Rituximab – A drug given after the procedure is complete, to kill the B cells, which have incorrect memory to cause inflammation.

Days

Day -13 – Welcome and Testing

Day -12 – Medical HIstory

Day -11 – Chemo at clinic

Day -10 – Chemo at clinic

Day – 9 – Filgrastim at apartment. 7am, 7pm

Day – 8 – Filgrastim at apartment. 7am, 7pm

Day – 7 – Filgrastim at apartment. 7am, 7pm

Day – 6 – Filgrastim at apartment. 7am, 7pm

Day – 5 – Filgrastim at apartment. 7am, 7pm

Day – 4 – Filgrastim at apartment. 7am, 7pm

Day – 3 – Filgrastim at apartment. 7am, 7pm. Catheter Placement, Hospital Puebla

Day – 2 –  Cell Harvesting. Chemo – Clinic

Day – 1 – Chemo, Clinic

Day – 0 – Cell Placement, Clinic. Day of immune system rebirth.

Day +1 – Neutropenic, Apartment

Day +2 –  Neutropenic. Blood Samples, Filgrastrim, Apartment, Hemotology Consultation – Clinic

Day +3 – Filgrastrim, Apartment

Day +4, Blood Samples, Hemotology Consultation – Clinic

Day +5, Filgrastrim, Apartment

Day +6, Blood Samples, Filgrastrim, Apartment, Hemotology Consultation – Clinic

Day +7, Filgrastrim, Apartment

Day +8, Blood Samples, Filgrastrim, Apartment, Hemotology Consultation – Clinic

Day +9, Filgrastrim, Aparment

Day +10, Blood Samples, Filgrastrim, Apartment, Hemotology Consultation – Clinic

Day +11, Filgrastrim, Apartment

Day +12, Blood samples, Filgrastrim scheduled if needed, Doctor evaluation at clinic, Rituximab application.

Day +13, Go Home